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© Research
Publication : BMC systems biology

Mimoza: web-based semantic zooming and navigation in metabolic networks

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BMC systems biology - 26 Feb 2015

Zhukova A, Sherman DJ

Link to Pubmed [PMID] – 25889977

BMC Syst Biol 2015;9:10

BACKGROUND: The complexity of genome-scale metabolic models makes them quite difficult for human users to read, since they contain thousands of reactions that must be included for accurate computer simulation. Interestingly, hidden similarities between groups of reactions can be discovered, and generalized to reveal higher-level patterns.

RESULTS: The web-based navigation system Mimoza allows a human expert to explore metabolic network models in a semantically zoomable manner: The most general view represents the compartments of the model; the next view shows the generalized versions of reactions and metabolites in each compartment; and the most detailed view represents the initial network with the generalization-based layout (where similar metabolites and reactions are placed next to each other). It allows a human expert to grasp the general structure of the network and analyze it in a top-down manner

CONCLUSIONS: Mimoza can be installed standalone, or used on-line at http://mimoza.bordeaux.inria.fr/ , or installed in a Galaxy server for use in workflows. Mimoza views can be embedded in web pages, or downloaded as COMBINE archives.

http://www.ncbi.nlm.nih.gov/pubmed/25889977