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© Therese Couderc, Marc Lecuit
Publication : FEBS letters

MicroRNAs in the interaction between host and bacterial pathogens

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 12 Aug 2014

Maudet C, Mano M, Eulalio A

Link to Pubmed [PMID] – 25128459

FEBS Lett. 2014 Nov;588(22):4140-7

MicroRNAs (miRNAs) are small non-coding RNAs with a central role in the post-transcriptional control of gene expression, that have been implicated in a wide-range of biological processes. Regulation of miRNA expression is increasingly recognized as a crucial part of the host response to infection by bacterial pathogens, as well as a novel molecular strategy exploited by bacteria to manipulate host cell pathways. Here, we review the current knowledge of bacterial pathogens that modulate host miRNA expression, focusing on mammalian host cells, and the implications of miRNA regulation on the outcome of infection. The emerging role of commensal bacteria, as part of the gut microbiota, on host miRNA expression in the presence or absence of bacterial pathogens is also discussed.

https://www.ncbi.nlm.nih.gov/pubmed/25128459