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© Research
Publication : Environmental microbiology

Metagenomic assessment of the interplay between the environment and the genetic diversification of Acinetobacter

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Environmental microbiology - 02 Oct 2017

Garcia-Garcera M, Touchon M, Brisse S, Rocha EPC

Link to Pubmed [PMID] – 28967182

Environ. Microbiol. 2017 Oct;

Most bacteria have poorly characterized environmental reservoirs and unknown closely related species. This hampers the study of bacterial evolutionary ecology because both the environment and the genetic background of ancestral lineages are unknown. We combined metagenomics, comparative genomics and phylogenomics to overcome this limitation, to identify novel taxa and to propose environments where they can be isolated. We applied this method to characterize the ecological distribution of known and novel lineages of Acinetobacter spp. We observed two major environmental transitions at deep phylogenetic levels, splitting the genus into three ecologically differentiated clades. One of these has rapidly shifted towards host-association by acquiring genes involved in bacteria-eukaryote interactions. We show that environmental perturbations affect species distribution in predictable ways: bovines have very diverse communities of Acinetobacter, unless they were administered antibiotics, in which case they show highly uniform communities of Acinetobacter spp. that resemble those of humans. Our results uncover the diversity of bacterial lineages, overpassing the limitations of classical cultivation methods and highlight the role of the environment in shaping their evolution.

https://www.ncbi.nlm.nih.gov/pubmed/28967182