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© Christelle Durand
Microscopie d'un neurone. Le marquage jaune montre les synapses.
Publication : Proceedings of the National Academy of Sciences of the United States of America

Long-term effects of chronic nicotine exposure on brain nicotinic receptors

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2007

Besson M, Granon S, Mameli-Engvall M, Cloëz-Tayarani I, Maubourguet N, Cormier A, Cazala P, David V, Changeux JP, Faure P

Link to Pubmed [PMID] – 17470777

Proc. Natl. Acad. Sci. U.S.A. 2007 May;104(19):8155-60

Chronic nicotine exposure results in long-term homeostatic regulation of nicotinic acetylcholine receptors (nAChRs) that play a key role in the adaptative cellular processes leading to addiction. However, the relative contribution of the different nAChR subunits in this process is unclear. Using genetically modified mice and pharmacological manipulations, we provide behavioral, electrophysiological, and pharmacological evidence for a long-term mechanism by which chronic nicotine triggers opposing processes differentially mediated by beta2*- vs. alpha7*nAChRs. These data offer previously undescribed insights into the understanding of nicotine addiction and the treatment of several human pathologies by nicotine-like agents chronically acting on beta2*- or alpha7*nAChRs.

http://www.ncbi.nlm.nih.gov/pubmed/17470777