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© Institut Pasteur
Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.
Publication : Advances in preventive medicine

Laboratory surveillance of rabies in humans, domestic animals, and bats in madagascar from 2005 to 2010

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Advances in preventive medicine - 21 Aug 2011

Reynes JM, Andriamandimby SF, Razafitrimo GM, Razainirina J, Jeanmaire EM, Bourhy H, Heraud JM

Link to Pubmed [PMID] – 21991442

Adv Prev Med 2011;2011:727821

Background. Rabies virus (RABV) has circulated in Madagascar at least since the 19th century. Objectives. To assess the circulation of lyssavirus in the island from 2005 to 2010. Materials and Methods. Animal (including bats) and human samples were tested for RABV and other lyssavirus using antigen, ribonucleic acid (RNA), and antibodies detection and virus isolation. Results. Half of the 437 domestic or tame wild terrestrial mammal brains tested were found RABV antigen positive, including 54% of the 341 dogs tested. This percentage ranged from 26% to 75% across the period. Nine of the 10 suspected human cases tested were laboratory confirmed. RABV circulation was confirmed in 34 of the 38 districts sampled. No lyssavirus RNA was detected in 1983 bats specimens. Nevertheless, antibodies against Lagos bat virus were detected in the sera of 12 among 50 Eidolon dupreanum specimens sampled. Conclusion. More than a century after the introduction of the vaccine, rabies still remains endemic in Madagascar.

http://www.ncbi.nlm.nih.gov/pubmed/21991442