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© Institut Pasteur
Cryptococcus neoformans
Publication : Memorias do Instituto Oswaldo Cruz

Introns in Cryptococcus

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Memorias do Instituto Oswaldo Cruz - 19 Feb 2018

Janbon G

Link to Pubmed [PMID] – 29513783

Mem. Inst. Oswaldo Cruz 2018;113(7):e170519

In Cryptococcus neoformans, nearly all genes are interrupted by small introns. In recent years, genome annotation and genetic analysis have illuminated the major roles these introns play in the biology of this pathogenic yeast. Introns are necessary for gene expression and alternative splicing can regulate gene expression in response to environmental cues. In addition, recent studies have revealed that C. neoformans introns help to prevent transposon dissemination and protect genome integrity. These characteristics of cryptococcal introns are probably not unique to Cryptococcus, and this yeast likely can be considered as a model for intron-related studies in fungi.

https://www.ncbi.nlm.nih.gov/pubmed/29513783