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© Xavier Montagutelli, Institut Pasteur
Publication : BioEssays : news and reviews in molecular, cellular and developmental biology

Interspecific resources: a major tool for quantitative trait locus cloning and speciation research.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in BioEssays : news and reviews in molecular, cellular and developmental biology - 01 Feb 2010

L'Hôte D, Laissue P, Serres C, Montagutelli X, Veitia RA, Vaiman D,

Link to Pubmed [PMID] – 20091755

Link to DOI [DOI] – 10.1002/bies.200900027

Bioessays 2010 Feb; 32(2): 132-42

Positional cloning of the quantitative trait locus (QTL) still encounters numerous difficulties, which explains why thousands of QTL have been mapped, while only a few have been identified at the molecular level. Here, we focus on a specific mapping tool that exists in plant and animal model species: interspecific recombinant congenic strains (IRCSs) or interspecific nearly isogenic lines (NILs). Such panels exhibit a much higher sequence diversity than intraspecific sets, thus enhancing the contrasts between phenotypes. In animals, it allows statistical significance to be reached even when using a limited number of individuals. Therefore, we argue that interspecific resources may constitute a major genetic tool for positional cloning and for understanding some bases of speciation mechanisms.

https://pubmed.ncbi.nlm.nih.gov/20091755