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© Research
Publication : Science (New York, N.Y.)

Interaction of a Golgi-associated kinesin-like protein with Rab6

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 23 Jan 1998

Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B

Link to Pubmed [PMID] – 9438855

Science 1998 Jan;279(5350):580-5

Rab guanosine triphosphatases regulate vesicular transport and membrane traffic within eukaryotic cells. Here, a kinesin-like protein that interacts with guanosine triphosphate (GTP)-bound forms of Rab6 was identified. This protein, termed Rabkinesin-6, was localized to the Golgi apparatus and shown to play a role in the dynamics of this organelle. The carboxyl-terminal domain of Rabkinesin-6, which contains the Rab6-interacting domain, inhibited the effects of Rab6-GTP on intracellular transport. Thus, a molecular motor is a potential effector of a Rab protein, and coordinated action between members of these two families of proteins could control membrane dynamics and directional vesicular traffic.

http://www.ncbi.nlm.nih.gov/pubmed/9438855