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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : Microbiology spectrum

Interaction between Intracellular Bacterial Pathogens and Host Cell Mitochondria

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbiology spectrum - 01 Mar 2019

Spier A, Stavru F, Cossart P

Link to Pubmed [PMID] – 30848238

Microbiol Spectr 2019 03;7(2)

Mitochondria are essential and highly dynamic organelles whose morphology is determined by a steady-state balance between fusion and fission. Mitochondrial morphology and function are tightly connected. Because they are involved in many important cellular processes, including energy production, cell-autonomous immunity, and apoptosis, mitochondria present an attractive target for pathogens. Here, we explore the relationship between host cell mitochondria and intracellular bacteria, with a focus on mitochondrial morphology and function, as well as apoptosis. Modulation of apoptosis can allow bacteria to establish their replicative niche or support bacterial dissemination. Furthermore, bacteria can manipulate mitochondrial morphology and function through secreted effector proteins and can also contribute to the establishment of a successful infection, e.g., by favoring access to nutrients and/or evasion of the immune system.

https://www.ncbi.nlm.nih.gov/pubmed/30848238