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© Michel-Robert Popoff
Clostridium difficile en microscopie à contraste de phase. On distingue des bactéries sporulées, non sporulées et d'autres en cours de lyse (destruction). Bactérie de l'environnement (sol, eau, foin, sable), elle est à l'origine d'infections nosocomiales survenant après un traitement antibiotique : Clostridium difficile prédomine alors que les autres bactéries de la flore intestinale ont été détruites. L'infection peut provoquer deux types de pathologies graves : les colites pseudo-membraneuses dont l'origine est quasiment due à 100 % à C. difficile et la diarrhée post-antibiothérapie due à C. difficile dans 30 % des cas de ces diarrhées.
Publication : Mobile genetic elements

Integration of erm(B)-containing elements through large chromosome fragment exchange in Clostridium difficile

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mobile genetic elements - 03 Feb 2015

Wasels F, Spigaglia P, Barbanti F, Monot M, Villa L, Dupuy B, Carattoli A, Mastrantonio P

Link to Pubmed [PMID] – 26442177

Mob Genet Elements 2015 Jan-Feb;5(1):12-16

In Clostridium difficile, erm(B) genes are located on mobile elements like Tn5398 and Tn6215. In previous studies, some of these elements were transferred by conjugation-like mechanisms, mobilized in trans by helper conjugative systems. In this study, we analyzed the genomes of several recipient strains that acquired either Tn5398 or Tn6215-like elements. We demonstrated that the integration of the transposons in the genome of the recipient cell was always due to homologous recombination events, involving exchange of large chromosomal segments. We did not observed transposon transfer to a C. difficile strain in presence of DNAse, suggesting that a possible transformation-like mechanism occurred in this recipient.

http://www.ncbi.nlm.nih.gov/pubmed/26442177