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© Therese Couderc, Marc Lecuit
Publication : Current opinion in microbiology

Innate immune responses to Listeria in vivo.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 01 Feb 2021

Maudet C, Levallois S, Disson O, Lecuit M,

Link to Pubmed [PMID] – 33307408

Link to DOI – S1369-5274(20)30141-710.1016/j.mib.2020.11.006

Curr Opin Microbiol 2021 Feb; 59(): 95-101

Listeria monocytogenes (Lm) is a foodborne bacterial pathogen that causes listeriosis, a severe infection that manifests as bacteremia and meningo-encephalitis mostly in immunocompromised individuals, and maternal-fetal infection. A critical pathogenic determinant of Lm relies on its ability to actively cross the intestinal barrier, disseminate systemically and cross the blood-brain and placental barriers. Here we illustrate how Lm both evades innate immunity, favoring its dissemination in host tissues, and triggers innate immune defenses that participate to its control.

https://pubmed.ncbi.nlm.nih.gov/33307408