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© Aline Bonnet, Institut Pasteur
Coupe transversale d’embryon de caille transgénique mbGFP à 18somites, au niveau du futur bourgeon de membre antérieur avec un marquage noyaux (bleu), GFP (vert) et actine (rouge) / Transversal section of a mbGFP transgenic quail embryo at 18-somite stage, at forelimb level, with nuclei (blue), GFP (green) and actin (red) labelling
Publication : Science (New York, N.Y.)

Cell movements at Hensen’s node establish left/right asymmetric gene expression in the chick

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 09 Apr 2009

Gros J, Feistel K, Viebahn C, Blum M, Tabin CJ

Link to Pubmed [PMID] – 19359542

Science 2009 May;324(5929):941-4

In vertebrates, the readily apparent left/right (L/R) anatomical asymmetries of the internal organs can be traced to molecular events initiated at or near the time of gastrulation. However, the earliest steps of this process do not seem to be universally conserved. In particular, how this axis is first defined in chicks has remained problematic. Here we show that asymmetric cell rearrangements take place within chick embryos, creating a leftward movement of cells around the node. It is the relative displacement of cells expressing sonic hedgehog (Shh) and fibroblast growth factor 8 (Fgf8) that is responsible for establishing their asymmetric expression patterns. The creation of asymmetric expression domains as a passive effect of cell movements represents an alternative strategy for breaking L/R symmetry in gene activity.

http://www.ncbi.nlm.nih.gov/pubmed/19359542