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© Therese Couderc, Marc Lecuit
Publication : Medecine et maladies infectieuses

Infectious encephalitis: Management without etiological diagnosis 48hours after onset

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medecine et maladies infectieuses - 15 Mar 2017

Fillatre P, Crabol Y, Morand P, Piroth L, Honnorat J, Stahl JP, Lecuit M

Link to Pubmed [PMID] – 28314470

Med Mal Infect 2017 May;47(3):236-251

INTRODUCTION: The etiological diagnosis of infectious encephalitis is often not established 48hours after onset. We aimed to review existing literature data before providing management guidelines.

METHOD: We performed a literature search on PubMed using filters such as “since 01/01/2000”, “human”, “adults”, “English or French”, and “clinical trial/review/guidelines”. We also used the Mesh search terms “encephalitis/therapy” and “encephalitis/diagnosis”.

RESULTS: With Mesh search terms “encephalitis/therapy” and “encephalitis/diagnosis”, we retrieved 223 and 258 articles, respectively. With search terms “encephalitis and corticosteroid”, we identified 38 articles, and with “encephalitis and doxycycline” without the above-mentioned filters we identified 85 articles. A total of 210 articles were included in the analysis.

DISCUSSION: Etiological investigations must focus on recent travels, animal exposures, age, immunodeficiency, neurological damage characteristics, and potential extra-neurological signs. The interest of a diagnosis of encephalitis for which there is no specific treatment is also to discontinue any empirical treatments initially prescribed. Physicians must consider and search for autoimmune encephalitis.

https://www.ncbi.nlm.nih.gov/pubmed/28314470