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© Research
Publication : PloS one

In vivo colocalisation of oskar mRNA and trans-acting proteins revealed by quantitative imaging of the Drosophila oocyte

Team: Biological Image Analysis
Member: Jean-Christophe Olivo-Marin
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 14 Jul 2009

Mhlanga MM, Bratu DP, Genovesio A, Rybarska A, Chenouard N, Nehrbass U, Olivo-Marin JC

Link to Pubmed [PMID] – 19597554

PLoS ONE 2009;4(7):e6241

Efficient mRNA transport in eukaryotes requires highly orchestrated relationships between nuclear and cytoplasmic proteins. For oskar mRNA, the Drosophila posterior determinant, these spatio-temporal requirements remain opaque during its multi-step transport process. By in vivo covisualization of oskar mRNA with Staufen, its putative trafficking protein, we find oskar mRNA to be present in particles distinct from Staufen for part of its transport. oskar mRNA stably associated with Staufen near the posterior pole. We observe oskar mRNA to oligomerize as hundreds of copies forming large particles which are necessary for its long range transport and localization. We show the formation of these particles occurs in the nurse cell nucleus in an Hrp48-dependent manner. We present a more refined model of oskar mRNA transport in the Drosophila oocyte.