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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.
Publication : Methods in molecular biology (Clifton, N.J.)

In Vivo Bacteriophage Biodistribution.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Methods in molecular biology (Clifton, N.J.) - 12 Jun 2020

Dufour N, Delattre R, Debarbieux L,

Link to Pubmed [PMID] – 29119437

Link to DOI [DOI] – 10.1007/978-1-4939-7395-8_11

Methods Mol. Biol. 2018 ; 1693(): 123-137

At the dawn of the renaissance of bacteriophage therapy, the full acceptation of bacteriophages as anti-bacterial agents requires the determination of their basic pharmacokinetic parameters. Such data, known for all conventional drugs used in human and veterinary medicine, allow optimizing dose regimens, efficacy, and help to limit toxicity. Here, we describe basic methods to experimentally obtain pharmacokinetic data and give also examples of data calculation to determine key parameters related to the biodistribution and elimination of bacteriophages in vivo.

https://pubmed.ncbi.nlm.nih.gov/29119437