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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : The Journal of cell biology

Impenetrable barriers or entry portals? The role of cell-cell adhesion during infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in The Journal of cell biology - 31 Oct 2011

Bonazzi M, Cossart P

Link to Pubmed [PMID] – 22042617

J. Cell Biol. 2011 Oct;195(3):349-58

Cell-cell adhesion plays a fundamental role in cell polarity and organogenesis. It also contributes to the formation and establishment of physical barriers against microbial infections. However, a large number of pathogens, from viruses to bacteria and parasites, have developed countless strategies to specifically target cell adhesion molecules in order to adhere to and invade epithelial cells, disrupt epithelial integrity, and access deeper tissues for dissemination. The study of all these processes has contributed to the characterization of molecular machineries at the junctions of eukaryotic cells that have been better understood by using pathogens as probes.

http://www.ncbi.nlm.nih.gov/pubmed/22042617