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© Therese Couderc, Marc Lecuit
Publication : Antimicrobial agents and chemotherapy

Iatrogenic Cushing’s syndrome induced by posaconazole.

Team: Biology of infection
Member: Olivier Lortholary
Member: Marc Lecuit
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Antimicrobial agents and chemotherapy - 01 Nov 2013

Pilmis B, Coignard-Biehler H, Jullien V, Hermine O, Touraine P, Lecuit M, Lortholary O,

Link to Pubmed [PMID] – 23979730

Link to DOI – 10.1128/AAC.00416-13

Antimicrob Agents Chemother 2013 Nov; 57(11): 5727-8

Iatrogenic Cushing’s syndrome is an undesirable outcome of glucocorticoids treatment. It can be increased by pharmacologic interactions. Glucocorticoid therapy, given in association with ritonavir, and some azole treatments are causes of iatrogenic Cushing’s syndrome. We present a patient with common-variable immunodeficiency who received 7 years of itraconazole therapy for bronchial colonization with Aspergillus in combination with inhaled fluticasone without any Cushingoid symptoms. After a switch to posaconazole, the patient developed Cushingoid symptoms.