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© Research
Publication : Open Biology

Human intestinal models to study interactions between intestine and microbes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Open Biology - 21 Oct 2020

Arturo Aguilar-Rojas, Jean-Christophe Olivo-Marin, Nancy Guillen

Link to Pubmed [PMID] – 33081633

Link to DOI – 10.1098/rsob.200199

Open Biol. 2020 Oct;10(10):200199

Implementations of suitable in vitro cell culture systems of the human intestine have been essential tools in the study of the interaction among organs, commensal microbiota, pathogens and parasites. Due to the great complexity exhibited by the intestinal tissue, researchers have been developing in vitro/ex vivo systems to diminish the gap between conventional cell culture models and the human intestine. These models are able to reproduce different structures and functional aspects of the tissue. In the present review, information is recapitulated on the most used models, such as cell culture, intestinal organoids, scaffold-based three-dimensional models, and organ-on-a-chip and their use in studying the interaction between human intestine and microbes, and their advantages and limitations are also discussed.

https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.200199