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© Research
Publication : Cell

Human Immunology through the Lens of Evolutionary Genetics

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell - 21 Mar 2019

Quintana-Murci L

Link to Pubmed [PMID] – 30901539

Cell 2019 Mar;177(1):184-199

Pathogen-imposed selection pressures have been paramount during human evolution. Detecting such selection signatures in ancient and modern human genomes can thus help us to identify genes of temporal and spatial immunological relevance. Admixture with ancient hominins and between human populations has been a source of genetic diversity open to selection by infections. Furthermore, cultural transitions, such as the advent of agriculture, have exposed humans to new microbial threats, with impacts on host defense mechanisms. The integration of population genetics and systems immunology holds great promise for the increased understanding of the factors driving immune response variation between individuals and populations.

https://www.ncbi.nlm.nih.gov/pubmed/30901539