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© Research
Publication : International journal of immunopathology and pharmacology

Human gastric epithelium produces IL-4 and IL-4delta2 isoform only upon Helicobacter pylori infection

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International journal of immunopathology and pharmacology - 01 Oct 2007

Orsini B, Vivas JR, Ottanelli B, Amedei A, Surrenti E, Galli A, Milani S, Pinzani P, Del Prete G, Surrenti C, Baldari CT, Touati E, D' Elios MM

Link to Pubmed [PMID] – 18179754

Int J Immunopathol Pharmacol 2007 Oct-Dec;20(4):809-18

Recent evidence suggests that interleukin-4 (IL-4) is related to mucosal tolerance by which an injurious immune response is prevented, suppressed or shifted to a non-injurious response. We investigated the expression of IL-4 and its splice variant isoform IL-4delta2 in gastric epithelial cells of healthy subjects and gastritis patients infected with Helicobacter pylori (H. pylori) with or without the cag pathogenicity island (cag-PAI). IL-4 and IL-4delta2 mRNAs were evaluated in microdissected gastric epithelium and in AGS cell lines co-cultured with H. pylori B128 or SS1 strains. IL-4 mRNA was consistently detected in microdissected gastric epithelial cells from healthy subjects. The IL-4 mRNA expression was low in H. pylori?infected patients, and markedly reduced in cag-PAI-positive ones. IL-4delta2 mRNA was expressed on gastric epithelium of H. pylori-infected patients, but not in healthy subjects. The IL-4delta2 expression was lower in cag-PAI-positive than in cag-PAI-negative H. pylori infected patients. AGS cells also produced IL-4 mRNA upon SS1 strain stimulation, whereas IL-4delta2 mRNA expression was detected in AGS co-cultured with either SS1 or B128 strains. An inverse correlation was documented between IL-4 and IL-4delta2 mRNA expression by microdissected gastric epithelial cells and the score of gastritis. IL-4, but not IL-4delta2, is expressed by gastric epithelium of healthy subjects, whereas IL-4delta2 and lesser IL-4 mRNA are detectable in the gastric epithelium of H. pylori-infected patients. Data suggest that gastric epithelial cells might regulate the balance between tolerance and immune response by the fine tuning of IL-4 and IL-4delta2 expression.

http://www.ncbi.nlm.nih.gov/pubmed/18179754