Search anything and hit enter
  • Teams
  • Members
  • Projects
  • Events
  • Calls
  • Jobs
  • publications
  • Software
  • Tools
  • Network
  • Equipment

A little guide for advanced search:

  • Tip 1. You can use quotes "" to search for an exact expression.
    Example: "cell division"
  • Tip 2. You can use + symbol to restrict results containing all words.
    Example: +cell +stem
  • Tip 3. You can use + and - symbols to force inclusion or exclusion of specific words.
    Example: +cell -stem
e.g. searching for members in projects tagged cancer
Search for
Count
IN
OUT
Content 1
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Content 2
  • member
  • team
  • department
  • center
  • program_project
  • nrc
  • whocc
  • project
  • software
  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinical Research Nurse
  • Clinician Researcher
  • Department Manager
  • Dual-education Student
  • Full Professor
  • Honorary Professor
  • Lab assistant
  • Master Student
  • Non-permanent Researcher
  • Nursing Staff
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
  • Head of Structure
  • Honorary President of the Departement
  • Labex Coordinator
Search
Go back
Scroll to top
Share
© Research
Publication : Biochimie

From GC skews to wavelets: a gentle guide to the analysis of compositional asymmetries in genomic data

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Biochimie - 29 Sep 2007

Touchon M, Rocha EP

Link to Pubmed [PMID] – 17988781

Biochimie 2008 Apr;90(4):648-59

Compositional asymmetries are pervasive in DNA sequences. They are the result of the asymmetric interactions between DNA and cellular mechanisms such as replication and transcription. Here, we review many of the methods that have been proposed over the years to analyse compositional asymmetries in DNA sequences. Among these we list GC skews, oligonucleotide skews and wavelets, which among other uses have been extensively employed to delimitate origins and termini of replication in genomes. We also review the use of multivariate methods, such as factorial correspondence analysis, discriminant analysis and analysis of variance, which allow assigning compositional strand asymmetries to the different biological processes shaping sequence composition. Finally, we review methods that have been used to infer substitution matrices and allow understanding the mutational processes underlying strand asymmetry. We focus on replication asymmetries because they have been more thoroughly studied, but the methods may be adapted, and often are, to other problems. Although strand asymmetry has been studied more frequently through compositional skews of nucleotides or oligonucleotides, we recall that, depending on the goal of the analysis, other methods may be more appropriate to answer certain biological questions. We also refer to programs freely available to analyse strand asymmetry.