Link to Pubmed [PMID] – 21994700
Viruses 2010 Aug;2(8):1666-80
A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.
Movie 1: Formation and dynamics of HIV virological synapse
Movie 2: Live imaging of HIV transmission
http://www.ncbi.nlm.nih.gov/pubmed/21994700