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© Research
Publication : Viruses

HIV-1 Virological Synapse: Live Imaging of Transmission

Team: Virus and Immunity
Member: Olivier Schwartz
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Viruses - 12 Aug 2010

Feldmann J, Schwartz O

Link to Pubmed [PMID] – 21994700

Viruses 2010 Aug;2(8):1666-80

A relatively new aspect of HIV-1 biology is the ability of the virus to infect cells by direct cellular contacts across a specialized structure, the virological synapse. This process was recently described through live cell imaging. Together with the accumulated knowledge on cellular and molecular structures involved in cell-to-cell transmission of HIV-1, the visualization of the virological synapse in video-microscopy has brought exciting new hypotheses on its underlying mechanisms. This review will recapitulate current knowledge with a particular emphasis on the questions live microscopy has raised.

 

HIV virological synapse : live transmission – Jérôme Feldmann et Olivier Schwartz – Viruses 2010
Supplementary data:

Movie 1: Formation and dynamics of HIV virological synapse

Movie 2: Live imaging of HIV transmission