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© Therese Couderc, Marc Lecuit
Publication : Epidemiology and infection

Herpes simplex encephalitis and management of acyclovir in encephalitis patients in France

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Epidemiology and infection - 07 Apr 2011

Stahl JP, Mailles A, De Broucker T,

Link to Pubmed [PMID] – 21470440

Epidemiol. Infect. 2012 Feb;140(2):372-81

This study reports on the clinical profiles of herpes simplex encephalitis (HSE) case-patients and the management of acyclovir prescriptions. We designed a study on the causes of encephalitis in France in 2007. Case-patients fulfilling the inclusion criteria were enrolled in all the hospitals that volunteered to participate. Fifty-five of 253 enrolled case-patients were diagnosed with HSE. Three (5%) HSE patients died and 48 (89%) were discharged with persistent neurological symptoms. All HSE patients were prescribed acyclovir, 10 of whom had a 2-week course; 42 a 3-week course; two received incomplete courses; and one received two courses of 21 days each due to relapse. The acyclovir dosage was reported for 45 adult HSE patients, 25 (53%) of whom received 10 mg/kg t.i.d. and 22 (47%) received 15 mg/kg t.i.d. The mortality rate was low despite 49% of patients being admitted to intensive-care units. A high dose of acyclovir was not associated with a better outcome in HSE patients. Most patients had persisting symptoms on discharge suggesting neuropsychological rehabilitation is an important issue for survivors.

http://www.ncbi.nlm.nih.gov/pubmed/21470440