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© Research
Publication : Colloids and surfaces. B, Biointerfaces

Growth factors-loaded stents modified with hyaluronic acid and heparin for induction of rapid and tight re-endothelialization

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Colloids and surfaces. B, Biointerfaces - 21 Jan 2016

Choi DH, Kang SN, Kim SM, Gobaa S, Park BJ, Kim IH, Joung YK, Han DK

Link to Pubmed [PMID] – 26928466

Colloids Surf B Biointerfaces 2016 May;141:602-10

Rapid re-endothelialization of damaged vessel lining efficiently prevents restenosis and thrombosis and restores original vascular functions. In this study, we designed a novel metallic stent with a heparin-modified surface and used different methods, including 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) and divinyl sulfone (DVS), to load growth factors. First we loaded heparin into a dopamine-conjugated hyaluronic acid (HA) coating to serve as a growth factor reservoir. In a second step, we took advantage of the heparin-binding domain of vascular endothelial growth factor (VEGF) and hepatocyte growth factor (HGF) to gain advanced re-endothelialization capabilities. We demonstrated that DVS technique offered higher amount of growth factor loading. In vitro assessment also showed better capillary-like structure formation and localized gap junctions when DVS coating was employed. This study suggested that growth factor loaded stent modified by HA and heparin provided the advantage to rapid and tight restoration of endothelium.

http://www.ncbi.nlm.nih.gov/pubmed/26928466