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© Therese Couderc, Marc Lecuit
Publication : Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi

Granulocyte colony stimulating factor-induced exacerbation of fungus-related immune restoration inflammatory syndrome: a case of chronic disseminated candidiasis exacerbation.

Team: Biology of infection
Member: Marc Lecuit
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi - 01 Aug 2010

Chandesris MO, Kelaidi C, Méchaï F, Bougnoux ME, Brousse N, Viard JP, Poirée S, Lecuit M, Hermine O, Lortholary O,

Link to Pubmed [PMID] – 20688295

Link to DOI – 10.1016/S1684-1182(10)60052-7

J Microbiol Immunol Infect 2010 Aug; 43(4): 339-43

Chronic disseminated candidiasis is a complication of the intensive therapies of hematological malignancies revealed during hematopoietic recovery, a context reminiscent of the immune restoration inflammatory syndrome in human immunodeficiency virus patients receiving antiretroviral therapy. We report a case of severe exacerbation of chronic disseminated candidiasis after pegylated granulocyte-colony stimulating factor administration. We emphasize the major inflammatory substrate of the disease and suggest that immune-modulating strategies such as hematopoietic growth factors, should be used cautiously in such patients.