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© Research
Publication : Pharmacogenomics

Genetic polymorphisms in low-dose methotrexate transporters: current relevance as methotrexate therapeutic outcome biomarkers.

Team: Mass Spectrometry for Biology
Team: Proteomics
Member: Rita Azevedo
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Pharmacogenomics - 01 Jan 2014

Lima A, Sousa H, Monteiro J, Azevedo R, Medeiros R, Seabra V,

Link to Pubmed [PMID] – 25340735

Link to DOI – 10.2217/pgs.14.116

Pharmacogenomics 2014 ; 15(12): 1611-35

Methotrexate (MTX) is used in low doses to treat a variety of diseases. Although the mechanism responsible for its therapeutic action is unknown, MTX membrane transport proteins (influx and/or efflux) can be major determinants of pharmacokinetics, adverse drug reactions and clinical response profiles. With progess in pharmacogenomics, the improvement of the prediction of patients’ therapeutic outcome treated with low doses of MTX will offer a powerful tool for the translation of transporter SNPs into clinical practice and will be essential to sustain a breakthrough in the field of personalized medicine. Therefore, this paper provides an update on the current data on SNPs in genes encoding low-dose MTX membrane transport proteins and their relevance as possible biomarkers of MTX therapeutic outcome.