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© Xavier Montagutelli, Institut Pasteur
Publication : Genome biology

Gene expression regulation in the context of mouse interspecific mosaic genomes.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Genome biology - 01 Jan 2008

L'Hôte D, Serres C, Veitia RA, Montagutelli X, Oulmouden A, Vaiman D,

Link to Pubmed [PMID] – 18752664

Link to DOI [DOI] – 10.1186/gb-2008-9-8-r133

Genome Biol. 2008 ; 9(8): R133

Accumulating evidence points to the mosaic nature of the mouse genome. However, little is known about the way the introgressed segments are regulated within the context of the recipient genetic background. To address this question, we have screened the testis transcriptome of interspecific recombinant congenic mouse strains (IRCSs) containing segments of Mus spretus origin at a homozygous state in a Mus musculus background.Most genes (75%) were not transcriptionally modified either in the IRCSs or in the parent M. spretus mice, compared to M. musculus. The expression levels of most of the remaining transcripts were ‘dictated’ by either M. musculus transcription factors (‘trans-driven’; 20%), or M. spretus cis-acting elements (‘cis-driven’; 4%). Finally, 1% of transcripts were dysregulated following a cis-trans mismatch. We observed a higher sequence divergence between M. spretus and M. musculus promoters of strongly dysregulated genes than in promoters of similarly expressed genes.Our study indicates that it is possible to classify the molecular events leading to expressional alterations when a homozygous graft of foreign genome segments is made in an interspecific host genome. The inadequacy of transcription factors of this host genome to recognize the foreign targets was clearly the major path leading to dysregulation.

https://pubmed.ncbi.nlm.nih.gov/18752664