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© Research
Publication : Mucosal immunology

From infection to immunotherapy: host immune responses to bacteria at the bladder mucosa

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mucosal immunology - 25 Sep 2013

Ingersoll MA, Albert ML

Link to Pubmed [PMID] – 24064671

Mucosal Immunol 2013 Nov;6(6):1041-53

The pathogenesis of urinary tract infection and mechanisms of the protective effect of Bacillus Calmette-Guerin (BCG) therapy for bladder cancer highlight the importance of studying the bladder as a unique mucosal surface. Innate responses to bacteria are reviewed, and although our collective knowledge remains incomplete, we discuss how adaptive immunity may be generated following bacterial challenge in the bladder microenvironment. Interestingly, the widely held belief that the bladder is sterile has been challenged recently, indicating the need for further study of the impact of commensal microorganisms on the immune response to uropathogen infection or intentional instillation of BCG. This review addresses the aspects of bladder biology that have been well explored and defines what still must be discovered about the immunobiology of this understudied organ.

http://www.ncbi.nlm.nih.gov/pubmed/24064671