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  • department
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  • program_project
  • nrc
  • whocc
  • project
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  • tool
  • patent
  • Administrative Staff
  • Assistant Professor
  • Associate Professor
  • Clinical Research Assistant
  • Clinician Researcher
  • Department Manager
  • Full Professor
  • Graduate Student
  • Honorary Professor
  • Lab assistant
  • Non-permanent Researcher
  • Permanent Researcher
  • Pharmacist
  • PhD Student
  • Physician
  • Post-doc
  • Prize
  • Project Manager
  • Research Associate
  • Research Engineer
  • Retired scientist
  • Technician
  • Undergraduate Student
  • Veterinary
  • Visiting Scientist
  • Deputy Director of Center
  • Deputy Director of Department
  • Deputy Director of National Reference Center
  • Deputy Head of Facility
  • Director of Center
  • Director of Department
  • Director of Institute
  • Director of National Reference Center
  • Group Leader
  • Head of Facility
  • Head of Operations
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  • Honorary President of the Departement
  • Labex Coordinator
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About

The thematic of our group, within the Dendritic Cell Immunology Unit, is immunology of the bladder with two broad projects focused on the related topics of response to uropathogens and response to immunotherapy for bladder cancer. The bladder is a unique and important mucosal barrier that remains relatively understudied. The two most prevalent diseases of the bladder are urinary tract infection (UTI), affecting nearly 50% of all women, and bladder cancer, which is the fourth most common malignancy in men and the 8th in women in the US and Europe. Importantly, both diseases have exorbitant health care associated costs and limited treatment options.

Our objective is to understand how adaptive immunity develops in the context of infection and immunotherapy in these two very different diseases. During UTI, adaptive immune responses are subverted by bladder-resident macrophages, leading to insufficient protection against challenge infection. By contrast, BCG immunotherapy for bladder cancer induces robust cytotoxic T cell responses and efficacious tumor immunity. Ongoing efforts are aimed at understanding these differences to improve treatments for both UTI and bladder cancer.

Courses

Innate Immunity MOOC

This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens. Register on : https://www.fun-mooc.fr/en/courses/innate-immunity/ Description: More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity […]

2022-01-14 09:00:00 2022-03-15 23:00:00 Europe/Paris Innate Immunity MOOC This MOOC describes the players and the whole orchestra involved in innate immunity against pathogens. Register on : https://www.fun-mooc.fr/en/courses/innate-immunity/ Description: More than a century ago, Elie Metchnikoff established the bases of cellular innate immunity […]

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