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  • Director of Center
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© Therese Couderc, Marc Lecuit
Publication : Microbes and infection

Focus on Chikungunya pathophysiology in human and animal models.

Team: Biology of infection
Member: Marc Lecuit
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Microbes and infection - 01 Dec 2009

Couderc T, Lecuit M,

Link to Pubmed [PMID] – 19737626

Link to DOI – 10.1016/j.micinf.2009.09.002

Microbes Infect 2009 Dec; 11(14-15): 1197-205

Chikungunya virus (CHIKV) is an arbovirus responsible for acute febrile arthralgia. It re-emerged abruptly in 2005 and caused a massive outbreak in the Indian Ocean region, and then extended to Asia. Here we review the pathophysiology of CHIKV infection, based on human and mouse studies, and also present prospects for prevention and therapy of this infection. Our results are discussed in the light of the current knowledge regarding other arthritogenic Alphaviruses.