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© Research
Publication : Nucleosides, nucleotides & nucleic acids

Fluorinated peptide nucleic acid

Team: Bioorganic chemistry of nucleic acids
Member: Marcel Hollenstein
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nucleosides, nucleotides & nucleic acids - 01 May 2003

Hollenstein M, Gautschi D, Leumann CJ

Link to Pubmed [PMID] – 14565377

Nucleosides Nucleotides Nucleic Acids 2003 May-Aug;22(5-8):1191-4

The fluorinated olefinic peptide nucleic acid analogue (F-OPA) monomer containing the base thymine was synthesised in 13 steps. PNAs containing this unit were prepared and their pairing properties assessed by means of UV-melting experiments.