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© Research
Publication : Current opinion in microbiology

Evolutionary patterns in prokaryotic genomes

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Current opinion in microbiology - 15 Oct 2008

Rocha EP

Link to Pubmed [PMID] – 18838127

Curr. Opin. Microbiol. 2008 Oct;11(5):454-60

Prokaryotic genomics is shifting towards comparative approaches to unravel how and why genomes change over time. Both phylogenetic and population genetics approaches are required to dissect the relative roles of selection and drift under these conditions. Lineages evolve adaptively by selection of changes in extant genomes and the way this occurs is being explored from a systemic and evolutionary perspective to understand how mutations relate with gene repertoire changes and how both are contextualized in cellular networks. Through an increased appreciation of genome dynamics in given ecological contexts, a more detailed picture of the genetic basis of prokaryotic evolution is emerging.

http://www.ncbi.nlm.nih.gov/pubmed/18838127