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© Research
Publication : Science (New York, N.Y.)

Evolutionary history of Salmonella typhi

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Science (New York, N.Y.) - 24 Nov 2006

Roumagnac P, Weill FX, Dolecek C, Baker S, Brisse S, Chinh NT, Le TA, Acosta CJ, Farrar J, Dougan G, Achtman M

Link to Pubmed [PMID] – 17124322

Science 2006 Nov;314(5803):1301-4

For microbial pathogens, phylogeographic differentiation seems to be relatively common. However, the neutral population structure of Salmonella enterica serovar Typhi reflects the continued existence of ubiquitous haplotypes over millennia. In contrast, clinical use of fluoroquinolones has yielded at least 15 independent gyrA mutations within a decade and stimulated clonal expansion of haplotype H58 in Asia and Africa. Yet, antibiotic-sensitive strains and haplotypes other than H58 still persist despite selection for antibiotic resistance. Neutral evolution in Typhi appears to reflect the asymptomatic carrier state, and adaptive evolution depends on the rapid transmission of phenotypic changes through acute infections.

http://www.ncbi.nlm.nih.gov/pubmed/17124322