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© Research
Publication : Evolutionary applications

Evolutionary genetics as a tool to target genes involved in phenotypes of medical relevance

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Evolutionary applications - 01 Feb 2009

Heyer E, Quintana-Murci L

Link to Pubmed [PMID] – 25567848

Evol Appl 2009 Feb;2(1):71-80

There is an increasing interest in detecting genes, or genomic regions, that have been targeted by natural selection. Indeed, the evolutionary approach for inferring the action of natural selection in the human genome represents a powerful tool for predicting regions of the genome potentially associated with disease and of interest in epidemiological genetic studies. Here, we review several examples going from candidate gene studies associated with specific phenotypes, including nutrition, infectious disease and climate adaptation, to whole genome scans for natural selection. All these studies illustrate the power of the evolutionary approach in identifying regions of the genome having played a major role in human survival and adaptation.

http://www.ncbi.nlm.nih.gov/pubmed/25567848