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© Christine Schmitt, Anubis Vega Rua, Jean-Marc Panaud
Tête de moustique femelle Aedes albopictus, vecteur du virus de la dengue et du chikungunya. Microphotographie électronique à balayage, image colorisée.
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell reports - 15 Dec 2020

Mondotte JA, Gausson V, Frangeul L, Suzuki Y, Vazeille M, Mongelli V, Blanc H, Failloux AB, Saleh MC,

Link to Pubmed [PMID] – 33326778

Link to DOI – S2211-1247(20)31495-910.1016/j.celrep.2020.108506

Cell Rep 2020 Dec; 33(11): 108506

Transgenerational immune priming (TGIP) allows memory-like immune responses to be transmitted from parents to offspring in many invertebrates. Despite increasing evidence for TGIP in insects, the mechanisms involved in the transfer of information remain largely unknown. Here, we show that Drosophila melanogaster and Aedes aegypti transmit antiviral immunological memory to their progeny that lasts throughout generations. We observe that TGIP, which is virus and sequence specific but RNAi independent, is initiated by a single exposure to disparate RNA viruses and also by inoculation of a fragment of viral double-stranded RNA. The progeny, which inherit a viral DNA that is only a fragment of the viral RNA used to infect the parents, display enriched expression of genes related to chromatin and DNA binding. These findings represent a demonstration of TGIP for RNA viruses in invertebrates, broadly increasing our understanding of the immune response, host genome plasticity, and antiviral memory of the germline.

https://pubmed.ncbi.nlm.nih.gov/33326778