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© Pierre Gounon
Entrée de Listeria dans une cellule épithéliale (Grossissement X 10000). Image colorisée.
Publication : FEBS letters

EVH1/WH1 domains of VASP and WASP proteins belong to a large family including Ran-binding domains of the RanBP1 family

Team: Bacteria-Cell Interactions
Member: Pascale Cossart
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 18 Dec 1998

Callebaut I, Cossart P, Dehoux P

Link to Pubmed [PMID] – 9883880

FEBS Lett. 1998 Dec;441(2):181-5

The two cytoskeletal proteins VASP and WASP and the protein Homer share a conserved domain, currently designated the WHI domain (WASP homology domain 1) or EVH1 domain (ENA/VASP homology domain 1), which could play an important role in various cellular events such as transport, folding of proteins, and signal transduction. We report here additional occurrences of this domain in Ran-binding proteins of the RanBP1 family and various others proteins, or putative proteins of eukaryotic organisms, suggesting that the EVH1/WH1 domain may be more widely used than originally thought.