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© Research
Publication : Journal of assisted reproduction and genetics

Effect of temozolomide on male gametes: an epigenetic risk to the offspring?

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Journal of assisted reproduction and genetics - 08 May 2013

Berthaut I, Montjean D, Dessolle L, Morcel K, Deluen F, Poirot C, Bashamboo A, McElreavey K, Ravel C

Link to Pubmed [PMID] – 23652788

J. Assist. Reprod. Genet. 2013 Jun;30(6):827-33

Temozolomide is an oral alkylating agent with proven efficacy in recurrent high-grade glioma. The antitumour activity of this molecule is attributed to the inhibition of replication through DNA methylation. However, this methylation may also perturb other DNA-dependent processes, such as spermatogenesis. The ability to father a child may be affected by having this treatment. Here we report a pregnancy and a baby born after 6 cures of temozolomide.

http://www.ncbi.nlm.nih.gov/pubmed/23652788