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© Research
Publication : PloS one

Distinctly different dynamics and kinetics of two steroid receptors at the same response elements in living cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in PloS one - 18 Aug 2014

Nenseth HZ, Dezitter X, Tesikova M, Mueller F, Klokk TI, Hager GL, Saatcioglu F

Link to Pubmed [PMID] – 25133404

PLoS ONE 2014;9(8):e105204

Closely related transcription factors (TFs) can bind to the same response elements (REs) with similar affinities and activate transcription. However, it is unknown whether transcription is similarly orchestrated by different TFs bound at the same RE. Here we have compared the recovery half time (t1/2), binding site occupancy and the resulting temporal changes in transcription upon binding of two closely related steroid receptors, the androgen and glucocorticoid receptors (AR and GR), to their common hormone REs (HREs). We show that there are significant differences at all of these levels between AR and GR at the MMTV HRE when activated by their ligands. These data show that two TFs bound at the same RE can have significantly different modes of action that can affect their responses to environmental cues.

http://www.ncbi.nlm.nih.gov/pubmed/25133404