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© Therese Couderc, Marc Lecuit
Publication : European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology

Disseminated toxoplasmosis in non-allografted patients with hematologic malignancies: report of two cases and literature review

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology - 18 Apr 2013

Scerra S, Coignard-Biehler H, Lanternier F, Suarez F, Charlier-Woerther C, Bougnoux ME, Gilquin J, Lecuit M, Hermine O, Lortholary O

Link to Pubmed [PMID] – 23595587

Eur. J. Clin. Microbiol. Infect. Dis. 2013 Oct;32(10):1259-68

Toxoplasmosis can be a severe opportunistic infection in patients with acquired immunodeficiency syndrome (AIDS), and also among solid organ transplant and allogeneic hematopoietic stem cell transplant (HSCT) patients. Patients with low-grade or chronic hematologic malignancies are treated with increasing immunosuppressive regimens and, therefore, represent an emerging population at risk for opportunistic diseases. We report here two cases of disseminated toxoplasmosis occurring in non-allografted hematologic patients with chronic lymphoproliferations. A review of 44 cases from the literature reveals that toxoplasmosis occurs increasingly in indolent B cell lymphoproliferative disorders. Aggressive lymphoproliferations, adenosine analogs, autologous HSCT, and the absence of chemoprophylaxis are the main risk factors for opportunistic toxoplasmosis. The central nervous system is the main organ involved. Fever is only present in half of all cases. Latent Toxoplasma cysts reactivation (LTCR) is the most common, but primary infection occurs in about 20% of cases. Global mortality is over 50%.

http://www.ncbi.nlm.nih.gov/pubmed/23595587