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© Research
Publication : FEBS letters

Development and regulation of RORγt(+) innate lymphoid cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in FEBS letters - 26 Mar 2014

Cording S, Medvedovic J, Cherrier M, Eberl G

Link to Pubmed [PMID] – 24681095

FEBS Lett. 2014 Nov;588(22):4176-81

RORγt(+) innate lymphoid cells (ILCs), or ILC3, play a fundamental role in the development of lymphoid tissues, as well as in homeostasis and defence of mucosal tissues. These cells produce IL-22, IL-17A and LTα1β2, key cytokines for the activation of epithelial defences and the recruitment of polymorphonuclear phagocytes. In the absence of ILC3, the early defence to infection and resistance to injury are compromised. Given the importance of ILC3 in mucosal immunity, significant efforts are made to discover their multiple functions and decipher their mode of action and regulation.

http://www.ncbi.nlm.nih.gov/pubmed/24681095