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Associate Professor
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Clinical Research Nurse
Clinician Researcher
Department Manager
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Honorary Professor
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Master Student
Non-permanent Researcher
Nursing Staff
Permanent Researcher
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PhD Student
Physician
Post-doc
Prize
Project Manager
Research Associate
Research Engineer
Retired scientist
Technician
Undergraduate Student
Veterinary
Visiting Scientist

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Deputy Director of Department
Deputy Director of National Reference Center
Deputy Head of Facility
Director of Center
Director of Department
Director of Institute
Director of National Reference Center
Group Leader
Head of Facility
Head of Operations
Head of Structure
Honorary President of the Departement
Labex Coordinator

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Febrile Temperature Critically Controls the Differentiation and Pathogenicity of T Helper 17 Cells

Systematic selection between age and household structure for models aimed at emerging epidemic predictions.

Corne d'Ammon (ou hippocampe) de renard atteint de rage sauvage. Coloration avec un conjugué fluorescent sur la nucléocapside du virus.

Publication : ChemMedChem

Design, Synthesis and Discovery of N,N’-Carbazoyl-aryl-urea Inhibitors of Zika NS5 Methyltransferase and Virus Replication.

Team: Lyssavirus epidemiology and neuropathology

Member: Wahiba Aouadi

Scientific Fields

Diseases

Organisms

Applications

Technique

Published in ChemMedChem - 17 Feb 2020

Spizzichino S, Mattedi G, Lauder K, Valle C, Aouadi W, Canard B, Decroly E, Kaptein SJF, Neyts J, Graham C, Sule Z, Barlow DJ, Silvestri R, Castagnolo D,

Link to Pubmed [PMID] – 31805205

Link to DOI – 10.1002/cmdc.201900533

ChemMedChem 2020 02; 15(4): 385-390

The recent outbreaks of Zika virus (ZIKV) infection worldwide make the discovery of novel antivirals against flaviviruses a research priority. This work describes the identification of novel inhibitors of ZIKV through a structure-based virtual screening approach using the ZIKV NS5-MTase. A novel series of molecules with a carbazoyl-aryl-urea structure has been discovered and a library of analogues has been synthesized. The new compounds inhibit ZIKV MTase with IC50 between 23-48 μM. In addition, carbazoyl-aryl-ureas also proved to inhibit ZIKV replication activity at micromolar concentration.

Published on: 17 Feb 2020