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© J.M. Ghigo (Institut Pasteur) and Brigite Arbeille (LBC-ME. Faculté de Médecine de Tours)
Colorized scanning electron microscopy of an E. coli biofilm developing on a glass surface
Publication : Nature Reviews Microbiology

Definitions and Guidelines for Research on Antibiotic Persistence

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Nature Reviews Microbiology - 12 Apr 2019

Balaban, N., S. Helaine, K. Lewis, B. Levin, C. Dehio, U. Jenal, D. Andersson, M. Heinemann, T. Tenson, D. Bumann, J. Michiels, A. Zinkernagel, W.-D. Hardt, M.-W. Tan, G. Storz, A. Harms, L.Van Melderen, J. Collins, M. Brynildsen, S. Fortune, J.-M. Ghigo, B. Aldridge, M. Ackermann, D. Hung, and A. Camilli

Link to Pubmed [PMID] – 30980069

Nat Rev Microbiol. 2019 Apr 12. doi: 10.1038/s41579-019-0196-3. [Epub ahead of print]

Increasing concerns about the rising rates of antibiotic therapy failure and advances in single-cell analyses have inspired a surge of research into antibiotic persistence. Bacterial persister cells represent a subpopulation of cells that can survive intensive antibiotic treatment without being resistant. Several approaches have emerged to define and measure persistence, and it is now time to agree on the basic definition of persistence and its relation to the other mechanisms by which bacteria survive exposure to bactericidal antibiotic treatments, such as antibiotic resistance, heteroresistance or tolerance. In this Consensus Statement, we provide definitions of persistence phenomena, distinguish between triggered and spontaneous persistence and provide a guide to measuring persistence. Antibiotic persistence is not only an interesting example of non-genetic single-cell heterogeneity, it may also have a role in the failure of antibiotic treatments. Therefore, it is our hope that the guidelines outlined in this article will pave the way for better characterization of antibiotic persistence and for understanding its relevance to clinical outcomes.

https://www.ncbi.nlm.nih.gov/pubmed/30980069