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© Laurent Debarbieux
Bactériophages sur la bactérie Escherichia coli 0104:H4 souche 55989.
Publication : Cell reports

Combination of in vivo phage therapy data with in silico model highlights key parameters for pneumonia treatment efficacy.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cell reports - 17 May 2022

Delattre R, Seurat J, Haddad F, Nguyen TT, Gaborieau B, Kane R, Dufour N, Ricard JD, Guedj J, Debarbieux L,

Link to Pubmed [PMID] – 35584666

Link to DOI – 10.1016/j.celrep.2022.110825

Cell Rep 2022 May; 39(7): 110825

The clinical (re)development of bacteriophage (phage) therapy to treat antibiotic-resistant infections faces the challenge of understanding the dynamics of phage-bacteria interactions in the in vivo context. Here, we develop a general strategy coupling in vitro and in vivo experiments with a mathematical model to characterize the interplay between phage and bacteria during pneumonia induced by a pathogenic strain of Escherichia coli. The model allows the estimation of several key parameters for phage therapeutic efficacy. In particular, it quantifies the impact of dose and route of phage administration as well as the synergism of phage and the innate immune response on bacterial clearance. Simulations predict a limited impact of the intrinsic phage characteristics in agreement with the current semi-empirical choices of phages for compassionate treatments. Model-based approaches will foster the deployment of future phage-therapy clinical trials.

https://pubmed.ncbi.nlm.nih.gov/35584666