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© Research
Publication : Cold Spring Harbour Perspectives in Biolology

Coevolution of the Organization and Structure of Prokaryotic Genomes.

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Cold Spring Harbour Perspectives in Biolology - 04 Jan 2016

Touchon M, Rocha EPC

Link to Pubmed [PMID] – 26729648

Cold Spring Harb Perspect Biol. 2016 Jan 4;8(1)

The cytoplasm of prokaryotes contains many molecular machines interacting directly with the chromosome. These vital interactions depend on the chromosome structure, as a molecule, and on the genome organization, as a unit of genetic information. Strong selection for the organization of the genetic elements implicated in these interactions drives replicon ploidy, gene distribution, operon conservation, and the formation of replication-associated traits. The genomes of prokaryotes are also very plastic with high rates of horizontal gene transfer and gene loss. The evolutionary conflicts between plasticity and organization lead to the formation of regions with high genetic diversity whose impact on chromosome structure is poorly understood. Prokaryotic genomes are remarkable documents of natural history because they carry the imprint of all of these selective and mutational forces. Their study allows a better understanding of molecular mechanisms, their impact on microbial evolution, and how they can be tinkered in synthetic biology.

http://cshperspectives.cshlp.org/content/8/1/a018168.long