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© Therese Couderc, Marc Lecuit
Publication : Vector borne and zoonotic diseases (Larchmont, N.Y.)

Chikungunya virus pathogenesis and immunity

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Vector borne and zoonotic diseases (Larchmont, N.Y.) - 01 Apr 2015

Gasque P, Couderc T, Lecuit M, Roques P, Ng LF

Link to Pubmed [PMID] – 25897810

Vector Borne Zoonotic Dis. 2015 Apr;15(4):241-9

Chikungunya virus (CHIKV) is an arbovirus associated with acute and chronic arthralgia that re-emerged in the Indian Ocean islands in 2005-2006 and is currently responsible for the ongoing outbreaks in the Caribbean islands and the Americas. We describe here the acute and chronic clinical manifestations of CHIKV in patients that define the disease. We also review the various animal models that have been developed to study CHIKV infection and pathology and further strengthened the understanding of the cellular and molecular mechanisms of CHIKV infection and immunity. A complete understanding of the immunopathogenesis of CHIKV infection will help develop the needed preventive and therapeutic approaches to combat this arbovirosis.

http://www.ncbi.nlm.nih.gov/pubmed/25897810