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© Research
Publication : Medecine sciences : M/S

[Chemical libraries dedicated to protein-protein interactions]

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Medecine sciences : M/S - 08 Apr 2015

Sperandio O, Villoutreix BO, Morelli X, Roche P

Link to Pubmed [PMID] – 25855285

Med Sci (Paris) 2015 Mar;31(3):312-9

The identification of complete networks of protein-protein interactions (PPI) within a cell has contributed to major breakthroughs in understanding biological pathways, host-pathogen interactions and cancer development. As a consequence, PPI have emerged as a new class of promising therapeutic targets. However, they are still considered as a challenging class of targets for drug discovery programs. Recent successes have allowed the characterization of structural and physicochemical properties of protein-protein interfaces leading to a better understanding of how they can be disrupted with small molecule compounds. In addition, characterization of the profiles of PPI inhibitors has allowed the development of PPI-focused libraries. In this review, we present the current efforts at developing chemical libraries dedicated to these innovative targets.

https://www.ncbi.nlm.nih.gov/pubmed/25855285