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© Melanie Blokesch, EPFL
Flagellated Vibrio cholerae
Publication : Annals of the New York Academy of Sciences

External guide sequence technology: a path to development of novel antimicrobial therapeutics

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Annals of the New York Academy of Sciences - 09 Apr 2015

Davies-Sala C, Soler-Bistué A, Bonomo RA, Zorreguieta A, Tolmasky ME

Link to Pubmed [PMID] – 25866265

Ann. N. Y. Acad. Sci. 2015 Apr;

RNase P is a ribozyme originally identified for its role in maturation of tRNAs by cleavage of precursor tRNAs (pre-tRNAs) at the 5′-end termini. RNase P is a ribonucleoprotein consisting of a catalytic RNA molecule and, depending on the organism, one or more cofactor proteins. The site of cleavage of a pre-tRNA is identified by its tertiary structure; and any RNA molecule can be cleaved by RNase P as long as the RNA forms a duplex that resembles the regional structure in the pre-tRNA. When the antisense sequence that forms the duplex with the strand that is subsequently cleaved by RNase P is in a separate molecule, it is called an external guide sequence (EGS). These fundamental observations are the basis for EGS technology, which consists of inhibiting gene expression by utilizing an EGS that elicits RNase P-mediated cleavage of a target mRNA molecule. EGS technology has been used to inhibit expression of a wide variety of genes, and may help development of novel treatments of diseases, including multidrug-resistant bacterial and viral infections.

http://www.ncbi.nlm.nih.gov/pubmed/25866265