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© Research
Publication : International immunology

Characterization of the developmental landscape of murine RORγt+ iNKT cells

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in International immunology - 30 Sep 2019

Klibi J, Li S, Amable L, Joseph C, Brunet S, Delord M, Parietti V, Jaubert J, Marie J, Karray S, Eberl G, Lucas B, Toubert A, Benlagha K

Link to Pubmed [PMID] – 31565740

Int. Immunol. 2019 Sep;

Invariant natural killer T cells (iNKT) expressing the retinoic acid receptor-related orphan receptor γt (RORγt) and producing IL-17 represent a minor subset of CD1d-restricted iNKT cells (iNKT17) in C57BL/6J (B6) mice. We aimed in this study to define the reasons for their low distribution and the sequence of events accompanying their normal thymic development. We found that RORγt+ iNKT cells have higher proliferation potential and a greater propensity to apoptosis than RORγt- iNKT cells. These cells do not likely reside in the thymus indicating that thymus emigration, and higher apoptosis potential, could contribute to RORγt+ iNKT cell reduced thymic distribution. Ontogeny studies suggest that mature HSAlow RORγt+ iNKT cells might develop through developmental stages defined by a differential expression of CCR6 and CD138 during which RORγt expression and IL-17 production capabilities are progressively acquired. Finally, we found that RORγt+ iNKT cells perceive a strong TCR signal that could contribute to their entry into a specific “Th17 like” developmental program influencing their survival and migration. Overall, our study proposes a hypothetical thymic developmental sequence for iNKT17 cells, which could be of great use to study molecular mechanisms regulating this developmental program.

https://www.ncbi.nlm.nih.gov/pubmed/31565740