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© Research
Publication : Mammalian genome : official journal of the International Mammalian Genome Society

Characterization of a putative type IV aminophospholipid transporter P-type ATPase

Scientific Fields
Diseases
Organisms
Applications
Technique

Published in Mammalian genome : official journal of the International Mammalian Genome Society - 01 Jan 2003

Flamant S, Pescher P, Lemercier B, Clément-Ziza M, Képès F, Fellous M, Milon G, Marchal G, Besmond C

Link to Pubmed [PMID] – 12532265

Mamm. Genome 2003 Jan;14(1):21-30

The P-type ATPases comprise a well-studied family of proteins involved in the active transport of charged substrates across biological membranes. Starting from a mouse bone marrow-derived macrophage cDNA library and using a signal peptide trapping strategy, we identified a new P-type ATPase family member. We characterized the genomic structure of this gene, named Atp10d, as well as its human counterpart. The presence of P-type ATPase consensus motifs and phylogenetic analysis showed that this gene is a member of the type IV, putative amphipath transporters subfamily. We showed that this gene is expressed in kidney and placenta. We also found that the C57BL/6 strain carries a constitutive stop codon in the sequence of Atp10d exon 12, whereas 14 other inbred mouse strains show an uninterrupted reading frame at this location. This mutation in C57BL/6 should lead to a non-functional protein, suggesting that this gene may not be essential. We discuss the involvement of the Atp10d gene in the fat-prone phenotype of the C57BL/6 strain and its physical mapping within a QTL associated with HDL-cholesterol levels.

https://www.ncbi.nlm.nih.gov/pubmed/12532265