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© Therese Couderc, Marc Lecuit
Publication : American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons

Cellulitis revealing a cryptococcosis-related immune reconstitution inflammatory syndrome in a renal allograft recipient.

Team: Biology of infection
Member: Marc Lecuit
Scientific Fields
Diseases
Organisms
Applications
Technique

Published in American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons - 10 Oct 2007

Lanternier F, Chandesris MO, Poirée S, Bougnoux ME, Mechai F, Mamzer-Bruneel MF, Viard JP, Galmiche-Rolland L, Lecuit M, Lortholary O,

Link to Pubmed [PMID] – 17927804

Am J Transplant 2007 Dec; 7(12): 2826-8

Immune reconstitution inflammatory syndrome (IRIS) has rarely been described in the course of disseminated cryptococcosis in solid organ transplant recipients. We report here the case of a renal transplant recipient who developed severe cellulitis in the context of Cryptococcus neoformans-associated IRIS while undergoing reduction of his immunosuppressive therapy. IRIS appeared concomitantly with a dramatic increase of blood CD4+ T cells (94-460/mm(3)) and required the administration of a short-term steroid therapy to resolve.